2026-10-13T16:12:58Z https://www.scidb.cn/oai

10.57760/sciencedb.38891 2026-06-11T15:24:42Z

2026-06-11 Liver transcriptome data of T2DM rats treated with MOTS-C and aerobic exercise doi:10.57760/sciencedb.38891 en Type 2 diabetes (T2DM) is a metabolic disease characterized by insulin resistance and liver glucose and lipid metabolism disorder. The liver, as the metabolic center of the body, plays a crucial role in the occurrence and development of T2DM. Previous studies have shown that aerobic exercise can significantly improve the metabolic status of T2DM patients, but its molecular mechanism has not been fully elucidated. In recent years, mitochondrial derived peptide MOTS-C has been shown to have the function of simulating exercise effects and regulating metabolic homeostasis. However, the combined intervention of MOTS-C and aerobic exercise on the transcriptome of T2DM liver still lacks systematic research. This project used high-fat diet combined with streptozotocin (STZ) - induced T2DM rats as a model, and administered MOTS-C intraperitoneal injection, aerobic treadmill exercise, and a combination of the two treatments. RNA seq technology was used to obtain liver transcriptome data for each group of rats. Through differential expression gene analysis, GO/KEGG enrichment analysis, and protein interaction network construction, key metabolic pathways and core genes were screened. Preliminary data shows that both MOTS-C and aerobic exercise intervention alone can partially reverse abnormal expression of gluconeogenesis, lipid synthesis, and inflammation related genes in the liver of T2DM rats; The combined intervention showed a synergistic effect, significantly enriched in the AMPK, PPAR, and insulin signaling pathways. Consistent with previous literature, exercise training can improve mitochondrial function by upregulating PGC-1 α, and this study found that MOTS-C can further enhance this effect. In addition, the combined intervention specifically regulated multiple novel long non coding RNAs, suggesting the existence of an epigenetic regulatory mechanism of motor MOTS-C cross-talk. The transcriptome data of this project provides important resources for revealing the molecular basis of MOTS-C simulation and enhancing exercise benefits, and also provides new ideas for developing "exercise mimetics" combination therapies for T2DM.  转录组; RNA-seq; 基因表达 Chen PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank