2026-10-13T11:58:52Z https://www.scidb.cn/oai

10.57760/sciencedb.40339 2026-06-24T19:16:45Z

2026-06-24 A unique intestinal desensitization strategy: Blocking membrane protease enrichment on macrophages by helminth-derived cystatin-like protein doi:10.57760/sciencedb.40339 en Egg allergies are prevalent worldwide and pose serious risks in children; however, a permanent cure is lacking. The desensitization of Trichinella spiralis-secreted cystatin-like protein (Ts-CLP) is an alternative to helminthic therapy for food allergies. Based on the allergy model in which Escherichia coli (E. coli) delivers ovalbumin (OVA) to the digestive system of OT-II mice, various therapeutic interventions related to Ts-CLP partially (delayed bone marrow-derived macrophages (BMDMs) intervention) or completely relieved inflammation and the disease course. Mechanistically, protein‒macrophage interaction-mediated blockade of the membrane enrichment of plasmin was identified as the important mode by which Ts-CLP-induced regulation manifests as high-level immunosuppressive cytokine secretion and impaired T-cell recruitment. In summary, Ts-CLP-incubated BMDMs can serve as an alternative for inflammation intervention in OVA-induced intestinal allergic diseases and the strategy of blocking protease enrichment on cell membrane is feasible to be applied in the treatment of type II inflammatory diseases. food allergy; helminthic therapy; alternative activated macrophages; receptor competitive binding; Trichinella spiralis wenjie shi PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank