2026-10-11T23:24:42Z https://www.scidb.cn/oai

10.57760/sciencedb.40889 2026-08-17T11:21:13Z

2026-08-17 Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription doi:10.57760/sciencedb.40889 en Here, we demonstrate that Ionomycin, a selective ionophore known to modulate mitochondrial homeostasis, similarly inhibits mitochondrial gene expression across cancer cell lines. Specifically, gene expression and nascent RNA profiling revealed a global downregulation of mitochondrial gene transcription in Jurkat T, THP-1, HeLa and NCI-H441 cells.  Ionomycin; Mitochondrial Gene Transcription; OXPHOS; Cell Proliferation. Lishen Wang Mingqiang Deng Dongmei He Diqin Lai Dongjun Liu Dengyong Zhu Zhenhua Zhang Peng Tang Chuanman Zhou Menghui Yin Xichen Bao EMBARGO https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank