2026-10-14T12:43:51Z https://www.scidb.cn/oai

10.57760/sciencedb.40896 2026-06-29T15:30:36Z

2026-06-29 Small molecules of Codonopsis Radix alleviate COPD by regulating the TACE/NF-κB signaling pathway doi:10.57760/sciencedb.40896 en Materials and methods 2.1. Reagents and materials 2.2. Preparation of CR 2.3. UPLC-MS/MS analysis of CR 2.4. Animal experiments 2.4.1. Animal and drug administration 2.4.2. Collection and Preparation of Plasma and Organ Samples 2.5. Histological Examination (H&E), Immunohistochemistry (IHC) and Immunofluorescence (IF) 2.6. Transcriptomic sequencing and analysis of pulmonary tissue 2.7. Network pharmacology analysis 2.8. Cell culture 2.9. Cell viability assay 2.10. ELISA for pro-inflammatory factors (TNF-α, IL-6, IL-1β) 2.11. Western blot analysis 2.12. cellular immunofluorescence staining 2.13. Statistical Evaluation Chronic obstructive pulmonary disease; Macrophage; Network pharmacology; Transcriptomic profiling Liu Shu RESTRICTED dataset Science Data Bank