2026-10-14T13:01:40Z https://www.scidb.cn/oai

10.57760/sciencedb.42103 2026-07-08T20:30:31Z

2026-07-08 Transcriptomic data of synergistic ferroptosis-apoptosis induction via a tumor-microenvironment-responsive Mn-doped ZIF-67 nanoplatform co-delivering ethyl ferulate for breast cancer therapy doi:10.57760/sciencedb.42103 en This dataset is derived from a study investigating the synergistic induction of ferroptosis and apoptosis by a Mn-doped ZIF-67 nanoplatform (Mn-ZIF-67@EF) for breast cancer therapy. We performed RNA-seq to profile the transcriptomic landscape of mouse breast cancer cells (4T1 cells) under different treatment conditions.The experimental design includes the following groups: Control, EF alone, Mn-ZIF-67 alone, and Mn-ZIF-67@EF combination treatment, each with three biological replicates.The dataset includes:Differential expression analysis (GO_Circlize.xlsx): Contains baseMean, log2FoldChange, p-value, adjusted p-value, and significance flags (Sig) for all genes.GO enrichment analysis (GSEA_GO_BP-Ridge.xlsx, GSEA_GO_CC-Ridge.xlsx, GSEA_GO_MF-Ridge.xlsx): Covers Biological Process (BP), Cellular Component (CC), and Molecular Function (MF) ontologies.KEGG pathway enrichment analysis (KEGG_Class_.xlsx): Includes background counts, candidate counts, enriched gene lists, P-values and Q-values for each pathway.Heatmap data (Heatmap_Top100_Symbols.xlsx): Provides raw counts of the top 100 differentially expressed genes across all samples for visualization of gene expression patterns. apoptosis; ferroptosis; ZIF-67 Yue Xu Yubin Qi Xuan Song Fuhong Liu Zongguo Sun Zengjin Wang Peng Gao EMBARGO https://creativecommons.org/licenses/by-nc/4.0/ dataset Science Data Bank