2026-10-14T14:23:05Z https://www.scidb.cn/oai

10.57760/sciencedb.42327 2026-07-09T14:58:10Z

2026-07-09 Microbial tryptophan metabolic reprogramming coordinates host PANoptosis to restrict Salmonella infection doi:10.57760/sciencedb.42327 en This dataset is derived from a translational biomedical study investigating the protective role of a microbiota-derived metabolite, indole-3-propionic acid (IPA), against infectious colitis. In this study, a porcine model (weaned crossbred piglets) was employed for in vivo experiments due to its exceptional physiological, immunological, and microbial metabolic similarities to humans. Human normal colon mucosal epithelial cells (NCM460) were further utilized for in vitro mechanistic validation. Salmonella; Colitis; Indole-3-propionic acid; CDK2; PANoptosis Huang Weihao Cheng Zhihao Zhou Changming Gu Guangguang Fangxiu Building Xia Yaoyao Zhao Xuan EMBARGO https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank