2026-10-14T22:54:01Z https://www.scidb.cn/oai

10.57760/sciencedb.42693 2026-07-10T15:14:33Z

2026-07-10 Single-cell dissection of cholesterol metabolism reveals cell-type-specific genes and hypercholesterolemia-associated remodeling doi:10.57760/sciencedb.42693 en Monocytes and macrophages were found to exhibit heightened activity in cholesterol transport and dynamic response pathways. Five monocyte-enriched cholesterol metabolism genes (CSF3R, FPR1, MNDA, MPEG1, and VCAN) were identified. Hypercholesterolemia was associated with increased abundance of macrophages, T cells, and NK cells, as well as decreased B cells and monocytes. Significant upregulation of pro-inflammatory genes such as VCAM1 in high-cholesterol conditions was revealed by differential gene expression analysis.​ Cholesterol metabolism; Single-cell RNA sequencing; Immune cells; Hypercholesterolemia; Blood samples; Cell-type-specific markers Jian Chu Jing Zhuang Shuwen Han Yujiu Liang Jing Mao Zian Zhang Caiyun Chu Xi Yang PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset http://www.doi.org/10.1152/ajpendo.00090.2026 Science Data Bank