2026-10-13T01:23:34Z https://www.scidb.cn/oai

10.57760/sciencedb.42865 2026-07-13T14:50:43Z

2026-07-13 β-D-N4-Hydroxycytidine inhibits canine parvovirus type 2 replication through transition-biased mutagenesis doi:10.57760/sciencedb.42865 en Canine parvovirus type 2 (CPV-2) causes severe disease in young dogs, yet no specific antiviral therapy is currently available. β-D-N4-hydroxycytidine (NHC) is a nucleoside analogue which can perform broad-spectrum antiviral activities against RNA viruses, but its activity against DNA viruses remains poorly characterized. Here, we evaluated the antiviral activity and potential mechanism of NHC against CPV-2 in vitro. NHC dose-dependently inhibited CPV-2a, CPV-2b, and CPV-2c replication in F81 cells with limited cytotoxicity.  Canine parvovirus type 2; β-D-N4-hydroxycytidine; nucleoside analogue; antiviral activity; transition-biased mutagenesis Xili Feng Chunlin Wang Zeyu Liu Jinchao Liu Maocheng Xia Xue Bai Jianhua Zhou PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank