2026-10-13T08:32:59Z https://www.scidb.cn/oai

10.57760/sciencedb.43472 2026-07-21T16:10:10Z

2026-07-21 Dendritic computation for abstract rule-based flexible decision-making doi:10.57760/sciencedb.43472 en Intelligent behavior involves flexible integration of sensory input and abstract rule knowledge. While dendritic computation is theorized to integrate distinct information streams, evidence linking it to flexible cognitive processing has been lacking. Using a rule-switching flexible categorization task, behavioral modeling, and subcellular-resolution two-photon imaging and optogenetics in mice, we found that within single layer 5 extratelencephalic neurons in the auditory cortex, apical dendrites preferentially encoded the inferred abstract rule, somata preferentially represented sensory stimuli, and choice signals were present in both compartments. Optogenetic dendritic inhibition impaired rule-dependent somatic choice coding, supporting a task-relevant integration across the dendritic and somatic compartments. These results identify a dendritic computation that implements a cognitive operation for flexible behavior within single cortical neurons. Dendritic computation; Flexible decision-making; Two-photon imaging; Auditory cortex Yuan Zhang Yanhe Liu Yachuang Hu Zhenkun Zhang Jie Du Lele Cui Qi Liu Lin Zhong Yu Xin Ruiming Chai Li Deng Jingwei Pan Jackie Schiller Ning-long Xu EMBARGO https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank