2026-10-12T04:01:17Z https://www.scidb.cn/oai

10.57760/sciencedb.43707 2026-07-21T16:14:39Z

2026-07-21 dataset for Multivalent Nanoparticles Activate T-dependent antibody response via Antigen Presentation by both B Cells and Dendritic Cells doi:10.57760/sciencedb.43707 en Multivalent nanoparticle vaccines elicit potent T cell-dependent (TD) antibody responses, yet how they initiate CD4+ T cell help remains unclear. Here, we show that antigen-specific B cells function as antigen-presenting cells (APCs) for CD4+ T cell priming across distinct nanoparticle platforms, including AP205 and ferritin. Using SARS-CoV-2 RBD and mpox virus A35 antigens, we demonstrate that B cells and dendritic cells (DCs) act redundantly to initiate early CD4+ T cell activation. In hosts lacking MHC class II expression on non-B cells, B cells alone were sufficient to drive naive CD4+ T cell proliferation. Moreover, B cell-mediated antigen presentation was required for inducing TD responses beyond the draining lymph nodes. These findings reveal a general mechanism by which multivalent nanoparticles engage B cells as APCs and highlight a potential strategy to enhance vaccine-induced immunity. nanoparticle; antibody response; antigen presentation Hou Baidong Hua Zhaolin PUBLIC https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank