2026-10-13T04:07:36Z https://www.scidb.cn/oai

10.57760/sciencedb.43970 2026-07-27T09:59:39Z

2026-07-27 De-identified dataset and analysis code for: Nonlinear Association Between Fever-to-IVIG Interval and Clinical Outcomes in Kawasaki Disease — A Retrospective Cohort Study of 6,921 Children doi:10.57760/sciencedb.43970 en This dataset supports the article "Nonlinear Association Between Fever-to-IVIG Interval and Clinical Outcomes in Kawasaki Disease: A Retrospective Cohort Study of 6,921 Children" (submitted to BMC Medicine). It comprises a de-identified, patient-level analytical dataset from a single-center retrospective cohort of 6,921 children diagnosed with Kawasaki disease (KD) and treated with initial intravenous immunoglobulin (IVIG, 2 g/kg) at Wuhan Children's Hospital between December 2012 and November 2025. The study investigates the nonlinear (U-shaped) association between the fever-to-IVIG interval and clinical outcomes, including IVIG resistance, coronary artery dilation (maximum Z-score >2.0), and aneurysm-level coronary involvement.The dataset contains one record per patient (6,921 rows × 44 variables), covering demographics (age in integer months, sex), principal clinical features, the primary exposure (fever-to-IVIG interval, days), timing variables, first-available pre-IVIG laboratory values (complete blood count, inflammatory markers, biochemistry, lymphocyte subsets, immunoglobulins, and complement), and four coronary and treatment outcome variables. Rigorous de-identification was applied: all direct identifiers and exact dates were removed; age is released in integer months; calendar year is released only as era categories; row order was randomly permuted; and extreme timing values were top-coded at 21 days. A full data dictionary, missing-data summary, de-identification protocol, and residual re-identification risk assessment are provided in the accompanying README file.An executable Python script (reproduce_analyses.py) is included, which reproduces all primary and sensitivity analyses reported in the article — including group comparisons (reference: 5–7 days), multivariable logistic regression with standardized covariates, nonlinearity likelihood-ratio tests, era-stratified analyses (2012–2018 vs. 2019–2025), and a sensitivity analysis restricted to complete KD — using only pandas, numpy, scipy, and statsmodels.Access: Controlled access under a data-use agreement (non-commercial academic research only; no re-identification attempts; no onward redistribution). Requests should be sent to the corresponding author and will be acknowledged within 30 days.Ethics: Approved by the Institutional Review Board of Wuhan Children's Hospital (2024R034-E01), with a waiver of informed consent for de-identified retrospective data. Kawasaki disease; intravenous immunoglobulin; fever-to-IVIG interval; IVIG resistance; coronary artery dilation; coronary artery aneurysm; treatment timing; retrospective cohort; pediatric cardiology Changjian Li Yong Zhang RESTRICTED dataset Science Data Bank