2026-10-14T18:39:23Z https://www.scidb.cn/oai

10.57760/sciencedb.44701 2026-07-30T11:11:01Z

2026-07-30 Integrative serum multi-omics identifies exposure-mediated lipid dysregulation as a unifying molecular signature of male infertility doi:10.57760/sciencedb.44701 en This dataset supports the study “Integrative serum multi-omics identifies exposure-mediated lipid dysregulation as a unifying molecular signature of male infertility” (Cen & Pan, 2026). Fasting serum from 231 men (112 male infertility, 119 normozoospermic fertile controls, classified per WHO 2021) was profiled by three LC–MS workflows (HILIC/reversed-phase metabolomics, lipidomics, and a targeted 80-chemical exposomics panel), each acquired in positive and negative ionization modes. After excluding non-shared samples, 251 complete-case samples (24 QC + 112 MI + 115 NC) were retained across all three omic layers. The package contains 1 004 mzXML files (four acquisition folders), six processed feature tables (249 metabolomic features, 2 687 lipid species across 32 classes, and 80 exposomic features), two LC–MS injection-order files, an aligned clinical metadata table, and a full original-to-renamed filename map. The dataset supports QC-RLSC drift correction, MOFA+/DIABLO multi-omics integration, machine-learning classification, and exposure–lipid–infertility mediation analysis. multi-omics; male infertility; lipid dysregulation Wenfeng Pan EMBARGO https://creativecommons.org/licenses/by-nc/4.0/ dataset Science Data Bank