2026-10-14T14:40:23Z https://www.scidb.cn/oai

10.57760/sciencedb.44794 2026-07-30T11:07:39Z

2026-07-30 Remodeled mechanical niches driving CXCR5 expression in paracortical CD8+ T cells dictates immunosurveillance of lymph node metastasis doi:10.57760/sciencedb.44794 en This dataset provides comparative ATAC-seq analysis of chromatin accessibility between CD8+CXCR5+ and CD8+CXCR5− T cells sorted from tumor-draining lymph nodes (TdLNs) at day 10 post-immunization. ATAC-seq libraries were prepared following standard protocols from single-cell suspensions, with intact nuclei obtained through cell-membrane lysis and organellar DNA effectively removed. The study revealed significantly enhanced chromatin accessibility at the Ikzf1 locus in CD8+CXCR5+ T cells. Ikzf1 encodes the transcription factor Ikaros, which plays critical regulatory roles in lymphocyte development and function. This dataset unveils the subset-specific epigenetic landscape of CXCR5+CD8+ T cells within the tumor microenvironment, providing valuable resources for understanding the molecular mechanisms underlying CD8+ T cell heterogeneity and functional differentiation in anti-tumor immune responses. CXCR5+ CD8+ T cells; Chromatin accessibility; Tumor-draining lymph node Jinghui Deng Xifen Zheng Yue Liang Yutong Liu Shichuan Liu Jin Yu Liang Tang Jie Chen Jiexiao Li Yiwen Lu Zihan Chen Zhaochen Yan Yabo Zhou Huafeng Zhang Jingwei Ma Jiadi Lv Ke Tang Bo Huang PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset Science Data Bank