2026-10-15T03:34:37Z https://www.scidb.cn/oai

10.57760/sciencedb.44925 2026-08-03T11:31:42Z

2026-08-03 Single-cell RNA sequencing dataset of gingival tissues from FAP global knockout mice with ligature-induced periodontitis doi:10.57760/sciencedb.44925 en This dataset contains single-cell RNA sequencing raw and processed data of gingival tissues from wild-type (WT) and global FAP knockout (FAP-KO) mice with ligature-induced periodontitis. Eight-week-old male C57BL/6 WT and FAP-KO mice were used to establish periodontitis models; gingival tissues and maxillary alveolar bone tissues were harvested 14 days after ligation for single-cell suspension preparation. Library construction was performed on domestic BGI DNBelab C4 single-cell platform, followed by sequencing on DNBSEQ-T7 platform. The dataset includes raw fastq reads, gene expression matrices, cell clustering annotation files, differentially expressed gene lists and cell-cell interaction results. Annotated cell populations include gingival fibroblasts, neutrophils, epithelial cells, macrophages and endothelial cells, focusing on expression profiles of FAP-positive stromal cells and NETs-related genes in neutrophils. This dataset generated by domestic single-cell sequencing platform can be reused for researches on stromal-immune crosstalk, FAP-mediated inflammatory and bone-destructive mechanisms, and single-cell atlas of periodontal microenvironment, providing transcriptomic resources for exploring molecular pathogenesis and therapeutic targets of periodontitis. Fibroblast activation protein; FAP knockout; gingival fibroblasts; neutrophils; mouse model Yijie Huang PUBLIC https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank