2026-10-14T21:06:24Z https://www.scidb.cn/oai

10.57760/sciencedb.45333 2026-08-04T10:59:42Z

2026-08-04 Transcriptomic profiling of RAS/BRAF wild-type colorectal cancer cells in response to cetuximab treatment doi:10.57760/sciencedb.45333 en This study was designed to investigate the transcriptomic alterations induced by cetuximab in RAS/BRAF wild-type (WT) colorectal cancer (CRC) cells. Two CRC cell lines (Caco-2 and SW48), confirmed as KRAS/NRAS/BRAF WT by ARMS-PCR, were treated with cetuximab or vehicle control. Total RNA was extracted and subjected to bulk RNA-sequencing (RNA-seq) to identify differentially expressed genes and affected signaling pathways following cetuximab treatment. Through Reactome, KEGG, and GO enrichment analyses of differentially expressed genes, we revealed the regulatory effects of cetuximab on metabolic pathways, particularly glycolysis, and on the expression of genes encoding multiple glycolytic enzymes. This dataset provides a valuable transcriptomic resource for understanding the molecular response mechanisms of cetuximab in wild-type CRC cells. Colorectal cancer; Cetuximab; RNA-seq; Glycolysis; Targeted therapy Qi Jiang Guifang Guo PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank