2026-10-12T23:57:12Z https://www.scidb.cn/oai

10.57760/sciencedb.45497 2026-08-17T11:22:05Z

2026-08-17 Dataset for exosomal miR‑4508 targets TRIM59 to promote EMT, M2 macrophage polarization and liver metastasis in cervical cancer doi:10.57760/sciencedb.45497 en This dataset supports the mechanistic study of cervical cancer, including cellular functional assays, exosome characterization, dual‑luciferase reporter assay, macrophage polarization detection, and in‑vivo liver metastasis data from nude mice models. Cellular data cover migration, invasion and EMT assays in SiHa and CaSki cells, flow cytometry for M1/M2 polarization of THP‑1‑derived M0 macrophages treated with cervical‑cancer‑derived exosomes, and dual‑luciferase validation for miR‑4508 targeting TRIM59. In‑vivo data include bioluminescence imaging, hepatic HE staining, flow‑cytometry‑based macrophage subset analysis and western blot results of metastatic lesions in BALB/c‑nude mice with tail‑vein‑induced liver metastasis. This dataset reveals that deficiency of exosomal miR‑4508 up‑regulates TRIM59, which accelerates EMT, migration and invasion of cervical cancer cells and triggers M2 macrophage polarization, thereby synergistically driving liver metastasis of cervical cancer. It provides experimental resources for studies on exosomal miRNA, tumor microenvironment and metastasis in cervical cancer. Cervical cancer; Exosome; miR‑4508; TRIM59; Epithelial‑mesenchymal transition; M2 macrophage; Liver metastasis Haixia Shang PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank