2026-10-13T09:33:55Z https://www.scidb.cn/oai

10.57760/sciencedb.45790 2026-08-12T09:41:01Z

2026-08-12 TIPHE: Tumor Innervation Phenotypes H&E Dataset for Oral Squamous Cell Carcinoma doi:10.57760/sciencedb.45790 en TIPHE (Tumor Innervation Phenotypes H&E Dataset) is a whole-slide histopathology dataset developed to support the study of tumor innervation phenotypes and tumor–nerve relationships in oral squamous cell carcinoma (OSCC). The dataset comprises 85 de-identified H&E-stained whole-slide images with pixel-level annotations of tumor epithelium and nerve structures, PNI-positive nerve masks where applicable, and valid-region masks for image-quality information. Tumor–nerve relationships are further annotated using three morphological categories: N1, tumor cells identified within the nerve structure; N2, direct tumor–nerve contact without tumor cells identified within the nerve structure; and N3, visible separation between tumor and nerve structures without direct contact. These N1–N3 categories describe morphological tumor–nerve relationships and are distinct from the separate pathological assessment of perineural invasion (PNI). The dataset also provides de-identified clinical metadata, label definitions, and predefined five-fold WSI-level partitions to facilitate standardized computational analysis and model evaluation. TIPHE is intended to support research in computational pathology, tumor and nerve segmentation, quantitative characterization of tumor innervation phenotypes, PNI-related research, and analysis of tumor–nerve spatial relationships. TIPHE; oral squamous cell carcinoma; tumor innervation Hao Cui Zhangpeng Gong Hong Qi Chonghao Yao Qidong Liu Shuwei Li Jiusong Ge Yihao Ding Di Zhang Jiashuai Liu Ming Yu Yue Guo Yongqi Liang Xiang Liang Ni Zhang Haoqi Tu Sijia Na Zeyu Gao Junbo Tu Chen Li PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank