2026-10-13T22:57:11Z https://www.scidb.cn/oai

10.57760/sciencedb.Partic.00018 2024-10-10T18:25:56Z

2024-10-10 Applications of artificial intelligence to lipid nanoparticle delivery doi:10.57760/sciencedb.partic.00018 en Lipid nanoparticles (LNPs) are nanocarriers composed of four lipid components and can be used for gene therapy, protein replacement, and vaccine development. However, LNPs also face several challenges, such as toxicity, immune activation, and low delivery efficiency. To overcome these challenges, artificial intelligence can be used to optimize the design and formulation of LNPs, as well as to predict their properties and performance. Moreover, antibody-targeted conjugation can be used to enhance the specificity and selectivity of LNPs by attaching an antibody that recognizes a specific antigen on the cell surface to LNPs. Artificial intelligence; Lipid nanoparticles; Antibody; Targeted conjugation Ye Yuan Yuqi Wu Jiabei Cheng Kaiyuan Yang Yilin Xia Hongguang Wu Xiaoyong Pan PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/https://doi.org/10.1016/j.partic.2023.11.014 Science Data Bank