2026-10-12T22:49:50Z https://www.scidb.cn/oai

10.57760/sciencedb.j00139.00068 2026-06-02T11:11:56Z

2026-06-02 Novel peptide identified from the skin of Kaloula pulchra frog doi:10.57760/sciencedb.j00139.00068 en A novel peptide which was named Cath-KP was identified from the skin of Kaloula pulchra frog. Cath-KP belongs to the Cathelicidin family with 37 amino acid residues (GCSGRFCNLFNNRRPGRLTLIHRPGGDKRTSTGLIYV). Cath-KP possesses a favorable antioxidant capability in both in vivo and in vitro. Cath-KP succesfully across the blood-brain barrier, strengthen protection against oxidative stress by promoting the expression of antioxidant enzymes and alleviating the accumulation of mitochondrial and intracellular ROS through regulating the activation of Sirt/Nrf2, FAK, and p38 signaling pathways, thereby ameliorate the damage towards nerve cells caused by stimulus. Cath-KP also affects the apoptosis process via modulating the expression of related protein including Bax and Bcl-2. In vivo, Cath-KP exerts a promising neuroprotective properties in MPTP-induced PD mice. Cathelicidin; Kaloula pulchra; Antioxidant Xueqing Xu RESTRICTED dataset http://www.doi.org/10.24272/j.issn.2095-8137.2023.101 Science Data Bank