2026-10-14T13:24:52Z https://www.scidb.cn/oai

10.57760/sciencedb.j00139.00120 2024-03-08T09:09:03Z

2024-03-08 Identification of Novel Mammalian Viruses in Tree Shrews (Tupaia belangeri chinensis) doi:10.57760/sciencedb.j00139.00120 en We used meta-transcriptomic sequencing to analyze plasma, oral and anal swab samples from 105 apparently healthy tree shrew individuals to identify potential zoonotic viruses. Eight mammalian viruses with complete genomes were identified, belonging to six viral families: Flaviviridae, Hepeviridae, Parvovirinae, Picornaviridae, Sedoreoviridae, and Spinareoviridae. We report, for the first time, a rotavirus in tree shrews. Of particular note were three viruses - hepacivirus1, parvovirus, and picornavirus - that exhibited low genetic similarity with previously reported viruses at the scale of whole genome and so were novel. Three other viruses - hepacivirus 2, hepatovirus A and hepevirus - exhibited high similarity to known viruses. Phylogenetic analyses revealed that the rotavirus and mammalian orthoreovirus identified in this study were closely related to known human and bat derived viruses, respectively. Tree shrew (Tupaia belangeri chinensis); Meta-transcriptomic sequencing; Mammalian viruses; Genomic analysis Hong Zhou Wei-Feng Shi Yong-Tang Zheng Ren-Rong Tian Xiu-Rong Wang Jin-Xuan Yang Yun-Xiao Wang Ming-Liang Zhao Xu-Dong Zhang Yu-Hua Ma Long-Bao Lv Edward C. Holmes PUBLIC https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank