2026-10-14T13:24:17Z https://www.scidb.cn/oai

10.57760/sciencedb.j00217.01706 2024-12-06T08:48:26Z

2024-12-06 Study on the changes of type 2 inherent lymphocyte (ILC2) in Brucella infection doi:10.57760/sciencedb.j00217.01706 en Objective This study investigated the variation and correlation of type 2 inherent lymphocytes (ILC2) and related factors in brucellosis, identified the immune role of ILC2 in the chronic brucellosis.Methods Forty-three patients with acute brucellosis and 45 patients with chronic brucellosis were compared with 49 healthy controls. The level of ILC2 in each group was detected by flow cytometry. The mRNA level of GATA3 in PBMC was detected by fluorescence quantitative PCR. The plasma levels of IL-33, ST2, IL-4 and IL-13 were detected by enzyme-linked immunosorbent assay (ELISA).Results The level of ILC2 cells in chronic brucellosis group was significantly higher than that in healthy control group and acute brucellosis group (P<0.01). The levels of GATA3 mRNA in PBMC, serum IL-33, IL-4 and IL-13 in chronic brucellosis group were significantly higher than those in healthy control group and acute brucellosis group (P<0.01). Correlation analysis showed that ILC2 cell level was positively correlated with GATA3 mRNA, IL-33, IL-4 and IL-13 levels, while ILC2 cell level was negatively correlated with ST2 levels. Conclusion The increase of ILC2 cells and its related factors is closely related to the chronic brucellosis, and may play an important role in the pathogenesis of brucellosis. Brucellosis; Type 2 intrinsic lymphocyte; GATA3; Interleukin-33; Interleukin-4; Interleukin-13 Zhengwei Yin Yuejie Zhu Juan Shi Yueyue He Jianbing Ding Quan Wang Fengbo Zhang PUBLIC https://creativecommons.org/licenses/by-nc-sa/4.0/ dataset Science Data Bank