2026-10-10T18:49:17Z https://www.scidb.cn/oai

10.57760/sciencedb.j00217.04145 2024-11-04T17:02:19Z

2024-11-04 Research progress of NLRP3 inflammasome in systemic lupus erythematosus doi:10.57760/sciencedb.j00217.04145 en Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, the etiology of which remains incompletely understood. Recent studies have demonstrated that NLRP3 inflammasome (NACHT, LRR and PYD domains-containing protein 3 inflammasome) plays an important role in the pathogenesis of SLE. This article seeks to comprehensively review the advancements in research concerning the NLRP3 inflammasome in SLE, encompassing recent developments in its activation mechanisms, modes of action, and therapeutic strategies. Systemic lupus erythematosus; NLRP3 inflammasome; Interleukin-1β; Pyroptosis JiangYan.WEI Shanshan.WEI Yujing.LIU Yi.WEI Xue.LI Lu.YAN PUBLIC https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank