2026-10-11T21:29:27Z https://www.scidb.cn/oai

10.57760/sciencedb.j00217.12735 2026-04-14T10:45:32Z

2026-04-14 Research Progress on Efferocytosis Dysfunction in Rheumatoid Arthritis doi:10.57760/sciencedb.j00217.12735 en Rheumatoid arthritis (RA) is a systemic disease characterized by chronic synovial inflammation, immune dysregulation, and progressive joint destruction. Macrophages serve as the core immune effector cells within the RA synovium, and their functional abnormalities are pivotal in sustaining inflammation and tissue damage. Efferocytosis refers to the highly efficient, immunosuppressive clearance of apoptotic cells by macrophages, forming the foundation for tissue homeostasis and the resolution of inflammation. However, the RA synovium exhibits a pronounced defect in efferocytosis, resulting in delayed clearance of apoptotic cells—particularly neutrophils—thereby precipitating secondary necrosis, the release of damage-associated molecular patterns (DAMPs), exposure of self-antigens, and chronic inflammation, ultimately establishing a vicious cycle. Preclinical studies targeting this mechanism have demonstrated that either activating TAM receptors or pro-resolving lipid mediators to enhance efferocytic signaling, or blocking its inhibitory pathways, can significantly attenuate inflammation and protect joints. Consequently, this review examines the impact of efferocytosis dysfunction on RA and proposes “pro-resolution”—rather than merely “anti-inflammatory”—strategies as precise therapeutic targets for clinical RA. Macrophages; Efferocytosis; Apoptotic cells; Rheumatoid arthritis; Resolution of inflammation Yongmei.GAO Wenjuan.XU Jiani.LU Jinchen.GUO EMBARGO https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank