2026-10-11T19:57:36Z https://www.scidb.cn/oai

10.57760/sciencedb.j00217.13725 2026-06-16T16:10:07Z

2026-06-16 Regulatory Mechanisms of Neuro-immune Interaction in the Skin-Brain Axis on Acupuncture Intervention in the Itch Circuitry of Psychodermatological Disorders doi:10.57760/sciencedb.j00217.13725 en Psychosomatic dermatological disorders are characterized by chronic pruritus, recurrent skin lesions, and emotional disturbances. The vicious cycle of "itch-scratch-emotion" severely impairs patients' health. Its pathological essence lies in the neuro-immune homeostatic imbalance and central network dysfunction regulated by the "skin-brain axis". Current mechanistic studies predominantly focus on downstream chemical sensory pathways, often overlooking the critical role of mechanical itch sensitization driven by tissue biomechanical remodeling. Acupuncture, a classic exogenous mechanical neuromodulation technique, not only induces the desensitization of peripheral mechanosensitive ion channels to block inflammatory cascades but also "bottom-up" reshapes the central itch-emotion brain network and autonomic nervous function, systematically restoring skin microenvironment homeostasis. Based on the skin-brain axis theory, this review systematically elucidates the regulatory mechanisms of the itch circuitry in acupuncture intervention for these disorders. It aims to break through the limitations of traditional single-target research, provide a multidimensional "mechanosensory-chemical-biological" coupling perspective, and offer a theoretical basis for constructing a whole-chain research paradigm for modern acupuncture mechanisms. Acupuncture; Psychodermatological disorders; Brain–skin axis; Neuroimmune interactions; Itch circuitry Xiao-lin.YE Xing-jie.ZHAO Shi-yi.HE Yao.SUN Yi-wei.XING Jing-chun.ZENG Han-yue.REN Si-min.FAN Meng-yao.LI Yin-ya.YANG Peng.Zhou Jing-jing.LI PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank