2026-10-11T19:10:08Z https://www.scidb.cn/oai

10.57760/sciencedb.j00217.13937 2026-07-09T09:50:20Z

2026-07-09 Oncogenic Mechanisms and Therapeutic Strategies of Phase Separation-Regulated Biomolecular Condensates in Gynecological Cancers doi:10.57760/sciencedb.j00217.13937 en Intracellular liquid-liquid phase separation (LLPS) is extensively involved in biological processes such as gene transcription, signal transduction, and DNA damage repair. In gynecological cancers (ovarian, cervical, and endometrial cancers), the high dependence on hormone receptor signaling and viral infections like HPV make the intracellular microenvironment highly susceptible to LLPS equilibrium disruption, thereby driving malignant progression.LLPS-driven nuclear condensates can abnormally activate the transcription of oncogenes or regulate alternative splicing, mRNA stability, and translation efficiency through RNA epigenetic modifications (e.g., m6A, m5C), leading to a massive increase in oncogenic protein synthesis. Furthermore, phase separation strengthens aerobic glycolysis in tumor cells by regulating metabolic enzymes such as PGK1, providing energy for rapid growth and inhibiting ferroptosis. Phase separation also significantly impacts protein homeostasis and stress response: under stress conditions, cancer cells form stress granules (SGs) through LLPS to evade apoptosis.Additionally, condensates formed via LLPS enhance DNA damage repair capabilities or create physical barriers, resulting in resistance to chemotherapy and PARP inhibitors. Constructing prognostic scoring models based on LLPS-related genes and targeting the phase separation state of specific proteins will provide new strategies and targets for individualized precision therapy in gynecological cancers. Liquid-liquid phase separation; Biomolecular condensates; Gynecological cancers; Oncogenic mechanisms; Therapeutic strategies Shengnan.LI Hongli.ZHAO Qingnan.FAN Lingyi.CAI Qi.CHEN Zhao Xiaoxuan PUBLIC https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank