2026-10-12T05:54:00Z https://www.scidb.cn/oai

10.57760/sciencedb.j00217.14275 2026-07-21T16:12:59Z

2026-07-21 Research Progress on Lactylation of Macrophage Polarization to Intervene in Renal Tubulointerstitial Fibrosis doi:10.57760/sciencedb.j00217.14275 en Tubulointerstitial fibrosis is a key step in the progression of chronic kidney disease, and the infiltration of inflammatory cells and the activation of inflammatory factors are among the key mechanisms underlying its pathogenesis. Macrophages are one of the key inflammatory cells involved in kidney injury; they can adapt their phenotype in response to environmental changes, polarizing into subpopulations with different functions and exerting both pro-fibrotic and anti-fibrotic effects. Phenotypic changes are closely related to epigenetic regulation. Lactylation, as a novel form of post-translational protein modification, plays a crucial role in regulating macrophage polarization and can direct the differentiation and maturation of macrophages into subtypes such as M1 and M2. Therefore, modulating macrophage polarization through lactylation may alter the progression of the renal inflammatory response, thereby influencing the course of tubulointerstitial fibrosis. This provides new research insights into the pathogenesis of renal fibrosis and also helps identify new therapeutic targets, develop new drugs, and improve the treatment of chronic kidney disease. This paper synthesizes recent relevant research with the aim of providing new research insights into the pathogenesis of renal fibrosis. Tubulointerstitial Fibrosis; Inflammatory Response; Lactylation; Macrophage Polarization Ying.Gao Yingying.Liu Zhaoan.Guo Xia.Li PUBLIC https://creativecommons.org/licenses/by-sa/4.0/ dataset Science Data Bank