2026-10-15T01:37:36Z https://www.scidb.cn/oai

10.57760/sciencedb.j00253.05382 2026-05-29T16:45:35Z

2026-05-29 A study on the association between the level of sphingomyelin in plasma and the risk of pancreatic cancer doi:10.57760/sciencedb.j00253.05382 en Objective To explore the association between the level of sphingomyelin (SM) in plasma and the risk of pancreatic cancer (PC).Methods Based on the Chinese Chronic Disease Prospective Study Cohort (CKB),7,152 study subjects were included at the baseline. The baseline plasma levels of SM were quantitatively detected using magnetic resonance technology. The Cox proportional hazards model was used to assess the association between SM and the risk of PC. Subgroup analysis was used to test the stability of this association under different population characteristics.Results By December 31, 2018, a total of 1,042 subjects had experienced PC events during the follow-up period. The results of the multivariate Cox regression analysis showed that after adjusting for confounding factors, the HR values (95%CI) of the Q2, Q3, and Q4 groups compared with the Q1 group were 1.288 (1.002~1.656), 1.388 (1.086~1.773), and 1.504 (1.187~1.904), respectively. Subgroup analysis indicated that the above associations were consistent in different age, gender, hypertension, and diabetes status populations (all interaction P>0.05).Conclusion The increase in SM levels in plasma is significantly associated with an increased risk of PC. There is a linear correlation between the two. SM may potentially serve as a biomarker for the early warning of PC. Lipid metabolomics; Pancreatic cancer; Sphingomyelin; Cohort study Yu.Tang Xiaoxin.Ye Peimin.Liu Liqiu.Qiu Xiaoyue.Liu Shan.Lin Shengshu.Wang Shanshan.Yang Yao.He Juan.Xie Miao.Liu PUBLIC https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank