2026-10-13T02:37:59Z https://www.scidb.cn/oai

10.57760/sciencedb.nb.00012 2026-04-13T10:15:09Z

2026-04-13 A Humanized Knock-In Mouse Model of the PSEN1 V97L Mutation from a Major Chinese Alzheimer’s Disease Pedigree Reveals Early Neuroinflammation doi:10.57760/sciencedb.nb.00012 en 数据使用GraphPad Prism软件8.0版（GraphPad;美国）。Shapiro–Wilk检验确认所有组的正态分布，P值超过0.05。该结果验证了数据保留以进行统计分析的有效性，并允许使用t检验。组均值比较采用无配对双尾t检验进行评估。结果以条形图表示为均值±标准差，统计显著性阈值为P <0.05。 Alzheimer's disease; PSEN1; Neuroinflammation; Cognitive impairments; Amyloid pathology Lu Dai Sirong Lv Huimin Gou ZIzhao Li Jiaying Li Yujia Wang Miaomiao Du Donghui Wu Kunhe Ma Na Wu Jing Zhang Baian Chen PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset http://www.doi.org/10.1007/s12264-026-01656-9 Science Data Bank