2026-10-11T16:27:24Z https://www.scidb.cn/oai

10.57760/sciencedb.nprd.000ck 2026-09-07T09:43:10Z

2026-09-07 Based on network pharmacology and cell experiments, the molecular mechanism of Rhizoma Acori graminei-Curcuma aromatic in treating precancerous lesions of gastric cancer was explored-original data doi:10.57760/sciencedb.nprd.000ck en The main compounds of Rhizoma Acori graminei-Curcuma aromatic were screened through databases such as TCMSP and TCMID, and their drug targets were obtained. PLGC-related targets were screened through multiple databases such as Gene Cards and OMIM. The PPI network diagram of Rhizoma Acori graminei-Curcuma aromatic in treating PLGC was constructed using Cytoscape software and String database. GO and KEGG analyses were conducted on the Metascape platform to identify biological pathways related to target proteins. Molecular docking was simulated using AutoDock Tools software. Cell experiments were conducted using the PLGC cell model induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The effects of Rhizoma Acori graminei-Curcuma aromatic on MNNG-induced cells (MC) were detected through cell proliferation and viability assay (CCK-8), cell scratch assay, Real-time PCR, and flow cytometry.  Network pharmacology; Rhizoma Acori graminei-Curcuma aromatic; Precancerous gastric lesions; PI3K-AKT; Apoptosis kunfeng li yangang wang PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset Science Data Bank