2026-10-14T14:06:38Z https://www.scidb.cn/oai

10.57760/sciencedb.nprd.00112 2026-02-24T17:36:59Z

2026-02-24 Antidepressant Mechanism of Acorus tatarinowii Volatile Oil via Inhibition of Microglial Polarization Through the TNF/NF-κB/NLRP3 Signaling Pathway doi:10.57760/sciencedb.nprd.00112 en This dataset is used for transcriptome sequencing technology to screen key differentially expressed genes in VOA antidepressant treatment and perform pathway enrichment analysis. Visualization analysis is performed on a bioinformatics platform. In vitro and in vivo experiments were conducted using Western Blot to detect the expression levels of TNF/NF - κ B/NLRP3 pathway proteins (p-NF - κ Bp65/NF - κ Bp65, p-I κ B α/I κ B α, TNF - α, PTGS2, NLRP3, Caspase-1, IL-1 β) and microglial M1/M2 phenotype markers (CD16/32, CD206). Data analysis and statistical graphs were performed using GraphPad Prism 9.  transcriptome sequencing; VOA antidepressant; TNF/NF-κB/NLRP3 pathway zheng tian tian Zhang Huiyu Cao Yuyu Lv Boyang Liu Siqi Tan Juanjuan Yang Hongyi EMBARGO https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank