2026-10-12T21:38:06Z https://www.scidb.cn/oai

10.57760/sciencedb.nprd.00168 2026-05-08T14:44:29Z

2026-05-08 Exploring the therapeutic mechanism of Patrinia villosa on metabolic dysfunction-associated steatohepatitis in mice based on transcriptomics and molecular docking doi:10.57760/sciencedb.nprd.00168 en The aim of this study is to investigate the mechanism by which Patrinia villosa extract (PVE) improves metabolic steatohepatitis (MASH). A high-fat and high sugar diet combined with fructose water was used to establish a MASH mouse model. Forty C57BL/6J mice were randomly divided into a normal control group, a model group, a low-dose group of Scutellaria baicalensis (0.17 g/kg), a high-dose group of Scutellaria baicalensis (0.34 g/kg), and an obeticolic acid group, and treated continuously for 8 weeks. Detect serum liver function indicators, blood lipid levels, oxidative stress indicators, and inflammatory factors; HE staining and Oil Red O staining were used to observe the pathological changes in the liver; Transcriptome sequencing analysis of differentially expressed genes; Western blot validation of core target protein expression; Molecular docking predicts the binding mode between active ingredients and target proteins.  Patrinia villosa; metabolic dysfunction-associated steatohepatitis; transcriptomics; molecular docking; lipid metabolism; oxidative stress wang yu PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank