2026-10-12T23:25:53Z https://www.scidb.cn/oai

10.57760/sciencedb.nprd.00188 2026-05-25T18:07:41Z

2026-05-25 Comparative study dataset of the antioxidant activities of total saponins, total flavonoids, and total polysaccharides of Panax notoginseng roots doi:10.57760/sciencedb.nprd.00188 en This study extracted total saponins (NTS), total flavonoids (NFT), and total polysaccharides (NTP) from the roots of Panax notoginseng, and purified them to determine their purity and content. Compare the free radical scavenging activity of NTS, NFT, and NTP through DPPH and ABTS free radical scavenging experiments; Using H ₂ O ₂ - induced skin fibroblasts (HFF) to establish an oxidative damage model, the intracellular malondialdehyde (MDA) content, superoxide dismutase (SOD) and glutathione (GSH) activity, reactive oxygen species (ROS) generation, as well as the expression levels of type I collagen, type III collagen, matrix metalloproteinase 1 (MMP1), and matrix metalloproteinase 3 (MMP3), were detected to comprehensively compare the improvement effects of the three on oxidative stress response. Further utilizing the UVB induced 3D skin injury model, the antioxidant activity of NTS, NFT, and NTP was comprehensively evaluated by examining the effects of ZO-1 and Claudin-1 expression.  Panax notoginseng root extract components; antioxidant; free radical scavenging; oxidative stress; barrier repair; 3D skin model huang jia wen He Zhiming Zhan Yi Wu Desong Cha Yufeng PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank