2026-10-12T00:12:49Z https://www.scidb.cn/oai

10.57760/sciencedb.nprd.00204 2026-06-14T14:36:01Z

2026-06-14 Mechanism of Glycyrrhizae Radix et Rhizoma-containing serum against postmenopausal osteoporosis based on network pharmacology and cell experiments- Raw Data doi:10.57760/sciencedb.nprd.00204 en Using ultra-high performance liquid chromatography high resolution mass spectrometry (UHPLC-HRMS) to detect the components of licorice that migrate into the bloodstream, drug targets were screened by TCMSP, STRING, and literature. PMOP disease targets were obtained from GeneCards and OMIM, and intersecting targets were obtained through Venn diagram. Cytoscope and STRING visualization were used, DAVID enrichment analysis was performed, and Autodock molecular docking was performed. Cell experiments were conducted to study the effect of licorice containing serum on MC3T3-E1 cell activity and ALP. RT qPCR and WB methods were used to detect the expression of PI3K-AKT signaling pathway related genes and proteins.  Molecular Docking; Network Pharmacology; PCR; WB Niu Pengxian Wang Siyu Li Quanmei Ma Xiaolan Yang Xiujuan Jinling RESTRICTED dataset Science Data Bank