2026-10-12T13:58:23Z https://www.scidb.cn/oai

10.57760/sciencedb.nprd.00303 2026-07-20T17:59:45Z

2026-07-20 Effects of cymbidium alkaloids on cartilage degeneration and synovial macrophage polarization in rats with knee osteoarthritis and its mechanisms- raw data doi:10.57760/sciencedb.nprd.00303 en Fifty SD rats were randomly divided into five groups (n=10) using a random number table method: Ctrl group, KOA group, Low SIN group, High SIN group, and High SIN+Coumermycin A1 group. Establish a KOA model by injecting sodium iodoacetate into the knee joint cavity. Observation of pathological changes in rat synovium and cartilage through histological staining. ELISA was used to detect the levels of TNF - α, IL-6, IL-4, and IL-10 in peripheral serum. Immunofluorescence staining was used to measure the levels of polarization markers in synovial macrophages. Western blot detection of protein expression levels related to the JAK2/STAT3 signaling pathway  sinomenine osteoarthritis; cartilage degeneration; synovitis; macrophage polarization; JAK2/STAT3 nie ming jun PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank