2026-10-15T05:46:10Z https://www.scidb.cn/oai

10.57760/sciencedb.xbyxb.00024 2024-09-04T18:29:03Z

2024-09-04 Relationship between tubal cilia and diseases associated with female infertility doi:10.57760/sciencedb.xbyxb.00024 en The movement function of the fallopian tube cilia (FTC) is closely related to factors such as the protein structure, movement direction, oscillation frequency, and amplitude of the cilia. These four factors are easily affected by abnormal gene expression, high hormone environment, and inflammatory factor stimulation in female infertility related diseases, leading to FTC movement disorders and increased risk of female infertility. Patients with primary ciliary dyskinesia (PCD) have congenital abnormalities in ciliary gene protein expression, leading to primary loss of FTC motor protein arms, motor structure defects, and polarity disruption. In the high testosterone environment of polycystic ovary syndrome (PCOS), the expression of major growth regulators in the cilia of the fallopian tubes is inhibited, resulting in a decrease in the number and length of cilia; Various common pathogens in pelvic inflammatory disease (PID) can stimulate and cause hydrosalpinx, adhesions, and scar changes, leading to the massive shedding of ciliated cells. In addition, the expression of peritoneal fluid and Wnt/β - catenin signaling in patients with endometriosis (EMT) significantly reduces CBF.  fallopian tube cilia; primary ciliary dyskinesia; polycystic ovary syndrome; pelvic inflammatory disease; endometriosis he liu qing Huang Yefang Xu Haofei Yin Xiaoxiao Luo Xinyu Huang Shiyu PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank