2026-10-12T02:25:51Z https://www.scidb.cn/oai

10.57760/sciencedb.xbyxb.00139 2026-04-08T12:09:42Z

2026-04-08 Figure 1 Schematic overview of common mechanisms of DILI doi:10.57760/sciencedb.xbyxb.00139 en Drugs are metabolized in the liver to generate reactive metabolites, which GSH and increase ROS, thereby triggering oxidative stress. This is followed by mitochondrial dysfunction-characterized by ATP depletion, opening of the PTP and/or MOMP, Cyt c release, and activation of the caspase cascade-ultimately leading to cell death. In addition, some drugs inhibit transporters such as the BSEP, causing intracellular bile acid accumulation and cholestatic toxicity. Meanwhile, drug-protein adducts and DAMP activate inflammatory and immune responses, promoting immune cell recruitment and exacerbating hepatocellular injury. drug-induced liver injury; western medicine; traditional Chinese medicine; acute liver failure; diagnostic biomarkers; genetic susceptibility; individualized pharmacotherapy DONG Jinrui PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank